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Mechanosensitivity and the eye: cells coping with the pressure

Abstract

The cells of the various organ systems in humans are subject to mechanical forces to which they must respond. Here the authors review what is known of the ways in which the cells of animals, ranging from the prokaryotic to humans, sense and transduce mechanical forces to respond to such stimuli. In what way this pertains to the eye, especially with respect to axial myopia and the pressure related disease of glaucoma, is then surveyed.

  • BDNF, brain derived neurotrophic factor
  • cAMP, cyclic adenosine monophosphate
  • DAG, diacyl glycerol
  • ECM, extracellular matrix
  • EGF, epidermal growth factor
  • IOP, intraocular pressure
  • IP3, inositol-3-phosphate
  • MAP-kinase, mitogen activated protein kinase
  • MMPs, matrix metalloproteinases
  • PDGF, platelet derived growth factor
  • PGF, prostaglandin F
  • PKA, protein kinase A
  • PKC, protein kinase C
  • RGC, retinal ganglion cells
  • TIMP, tissue inhibitor of MMP
  • TM, trabecular meshwork
  • VEGF, vascular endothelium growth factor
  • mechanosensitivity
  • eye
  • glaucoma
  • myopia
  • BDNF, brain derived neurotrophic factor
  • cAMP, cyclic adenosine monophosphate
  • DAG, diacyl glycerol
  • ECM, extracellular matrix
  • EGF, epidermal growth factor
  • IOP, intraocular pressure
  • IP3, inositol-3-phosphate
  • MAP-kinase, mitogen activated protein kinase
  • MMPs, matrix metalloproteinases
  • PDGF, platelet derived growth factor
  • PGF, prostaglandin F
  • PKA, protein kinase A
  • PKC, protein kinase C
  • RGC, retinal ganglion cells
  • TIMP, tissue inhibitor of MMP
  • TM, trabecular meshwork
  • VEGF, vascular endothelium growth factor
  • mechanosensitivity
  • eye
  • glaucoma
  • myopia
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