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  • Ocular decompression retinopathy following trabeculectomy with mitomycin C associated with familial amyloidotic polyneuropathy

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Ocular decompression retinopathy following trabeculectomy with mitomycin C associated with familial amyloidotic polyneuropathy
  1. M Wakita1,
  2. T Kawaji1,
  3. E Ando1,
  4. T Koga1,
  5. M Inatani1,
  6. H Tanihara1,
  7. Y Ando2
  1. 1Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan
  2. 2Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan
  1. Correspondence to: Takahiro Kawaji MD, Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan; kawag{at}white.plala.or.jp

http://dx.doi.org/10.1136/bjo.2005.082735

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    Familial amyloidotic polyneuropathy (FAP), a disorder inherited in autosomal dominant fashion, is characterised by systemic accumulation of polymerised mutated amyloidogenic TTR (ATTR) in peripheral nerves and in organs.1 We report two patients with FAP ATTR Y114C (a point mutation, from tyrosine to cysteine, at codon 114) who developed diffuse retinal haemorrhages immediately after uncomplicated trabeculectomy with mitomycin C (MMC).

    CASE REPORTS

    A woman underwent vitrectomy for vitreous opacity associated with FAP ATTR Y114C in the left eye when she was 34 years old and in the right eye when she was 35 years old. Neurological examination revealed that she had polyneuropathy and autonomic dysfunction, and she underwent liver transplantation at 34 years old. Thereafter, intraocular pressure …

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