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Intermediate uveitis (IU) is a potentially sight threatening condition seen in all racial groups. While the disorder is known to be associated with a number of systemic conditions, in the majority of cases, no underlying cause is found. Because autoimmunity may play a part in the pathogenesis of the disease, workers have studied the immunogenetics of non-familial IU and have suggested a role for certain HLA alleles such as HLA-A*28 HLA-DRB1*15, HLA-B*51, and B*08 in promoting susceptibility to the condition in predominantly white populations.1–5
While IU is a relatively common diagnosis in a uveitis clinic, constituting up to 15% of all uveitis cases seen,6 there are few reports in the literature of familial cases. In this study, a Hong Kong Chinese family was identified, some members of who …
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