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Validity of using vision-related quality of life as a treatment end point in intermediate and posterior uveitis
  1. Conor C Murphy1,
  2. Kathrin Greiner2,
  3. Jarka Plskova2,
  4. N Andrew Frost3,
  5. John V Forrester2,
  6. Andrew D Dick4
  1. 1Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia
  2. 2Department of Ophthalmology, University of Aberdeen, Aberdeen, UK
  3. 3Department of Ophthalmology, Torbay General Hospital and Peninsular Medical School, Torquay, UK
  4. 4Department of Clinical Sciences at South Bristol, University of Bristol, Bristol, UK
  1. Correspondence to: Dr C Murphy Department of Ophthalmology, Royal Perth Hospital, Victoria Square, Perth, WA 6000, Australia; conorcmurphy{at}


Aim: To evaluate the responsiveness of the Vision core module 1 (VCM1) vision-related quality of life (VR-QOL) questionnaire to changes in visual acuity in patients with posterior and intermediate uveitis and to validate its use as a clinical end point in uveitis.

Methods: Logarithm of the minimum angle of resolution visual acuity and VR-QOL using the VCM1 questionnaire were prospectively recorded in 37 patients with active posterior segment intraocular inflammation before starting systemic immunosuppression with ciclosporin, tacrolimus or the anti-tumour necrosis factor (TNF) agent, p55TNFr-Ig, and again 3 months later. Spearman analysis was used to correlate improvements in visual acuity and VR-QOL between baseline and 3 months.

Results: The correlation between changes in visual acuity and VR-QOL was moderate to good for the worse eye (r = 0.47, p = 0.003), but poor for the better eye (r = −0.05, p = 0.91). The responsiveness indices effect size and standardised response mean were 0.57 and 0.59, respectively, showing that the VCM1 questionnaire is moderately responsive to immunsosuppressive therapy for active uveitis.

Conclusion: Changes in VR-QOL measured with the VCM1 questionnaire correlated moderately well with changes in the worse eye visual acuity, suggesting that the VCM1 is a valid instrument for monitoring response to treatment in uveitis.

  • log MAR, logarithm of the minimum angle of resolution
  • SRM, standardised response mean
  • TNF, tumour necrosis factor
  • VCM1, vancomycin 1
  • VR-QOL, vision-related quality of life

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  • Funding: This study was supported by Fujisawa and the National Eye Research Centre, UK.

  • Competing interests: None.

  • Published Online First 14 September 2006