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Pars plana vitrectomy with peripheral retinotomy after injection of preoperative intravitreal tissue plasminogen activator: a modified procedure to drain massive subretinal haemorrhage
  1. Y Oshima1,
  2. M Ohji2,
  3. Y Tano1
  1. 1Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
  2. 2Department of Ophthalmology, Shiga University of Medical Science, Shiga, Japan
  1. Correspondence to: Dr Y Oshima Department of Ophthalmology, Osaka University Medical School, 2-2 Yamadaoka (Rm. E7), Suita, Osaka 565-0871, Japan; oshima{at}


Aims: To report outcome of a modified procedure for draining massive subretinal haemorrhages (SRHs).

Methods: The charts of eight consecutive eyes from eight patients with massive SRHs extending to the periphery and involving two or more quadrants with haemorrhagic and bullous retinal detachment were reviewed. Tissue plasminogen activator (tPA) was injected intravitreally 12–24 h preoperatively; vitrectomy was carried out with peripheral retinotomy, drainage of the SRH from the retinotomy using perfluorocarbon liquid and gas tamponade with prone positioning postoperatively.

Results: The preoperative visual acuities ranged from light perception to 20/200. Most of the subretinal haematomas moved postoperatively to the vitreous cavity through the peripheral retinotomy using perfluorocarbon liquid. Residual SRHs were drained from the anterior chamber at the bedside after prone positioning overnight. SRH recurred in one eye 14 months postoperatively and was successfully retreated. No other serious complications developed. The final visual acuity improved in seven eyes (range 20/1000–20/60). Polypoidal lesions in choroidal vasculatures were present in three of seven patients.

Conclusions: The technique seems safe and effective for treating massive SRH. However, visual recovery is limited by the underlying macular pathology. Polypoidal choroidal vasculopathy, other than age-related macular degeneration, may be another cause of massive SRHs.

  • AMD, age-related macular degeneration
  • logMAR, logarithm of minimal angle of resolution
  • SRH, subretinal haemorrhage
  • tPA, tissue plasminogen activator

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  • Published Online First 17 August 2006

  • Funding: This work was supported in part by a research grant (16591751, to YO) from the Ministry of Education, Science and Culture, Tokyo, Japan.

  • Competing interests: None.