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Comparison of acute structural and histopathological changes in human autopsy eyes after endoscopic cyclophotocoagulation and trans-scleral cyclophotocoagulation
  1. Mina B Pantcheva,
  2. Malik Y Kahook,
  3. Joel S Schuman,
  4. Robert J Noecker
  1. UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  1. Correspondence to: Dr Mina B Pantcheva 203 Lothrop Street, Pittsburgh, PA 15213, USA; minapantcheva{at}


Aim: To study the histological effects of trans-scleral cyclophotocoagulation (TCP) and endoscopic cyclophotocoagulation (ECP) on the ciliary body and other structures collected at autopsy and to compare with untreated controls.

Materials and methods: TCP and ECP were performed on human eyes at autopsy. Detailed histological evaluations were perfomed using light microscopy and scanning electron microscopy on treated eyes and compared with untreated controls.

Results: Histological changes were observed with both light microscopy and scanning electron microscopy for all treated tissues. Tissue treated with TCP showed pronounced tissue disruption of the ciliary body muscle and stroma, ciliary processes, and both pigmented and non-pigmented ciliary epithelium. ECP-treated tissue exhibited pronounced contraction of the ciliary processes with disruption of the ciliary body epithelium, sparing of the ciliary body muscle and less architectural disorganisation. The sclera was not affected by either laser treatment.

Conclusions: ECP treatment caused less damage to the ciliary body compared with TCP when evaluated by light microscopy and scanning electron microscopy. Compared with TCP, ECP seems to be a more selective form of cyclophotocoagulation, resulting in less tissue disruption while achieving the goal of destroying ciliary body epithelium.

  • ECP, endoscopic cyclophotocoagulation
  • IOP, intraocular pressure
  • TCP, trans-scleral cyclophotocoagulation

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  • Funding: Core Grant for Vision Research—EY080908, supported in part by an unrestricted grant from Research to Prevent Blindness and The Eye and Ear Foundation (Pittsburgh, PA).

  • Competing interests: RJN has received honoraria for speakerships for EndoOptiks.

  • Published Online First 20 September 2006

    The authors do not have a financial/proprietary interest in any of the devices, equipment, instruments or drugs discussed in this article.

    The results of this study have been presented at the American Glaucoma Society (AGS) meeting in Charlestown, South Carolina, USA, March 2006.

  • RJNis on the Speakers Bureau for EndoOptiks.