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We investigated whether vitreous levels of advanced glycation end products (AGEs) were positively correlated with vascular endothelial growth factor (VEGF) in patients with diabetic retinopathy patients sufficiently treated with retinal photocoagulation. Vitreous AGE and VEGF levels were significantly higher in patients with diabetes than in controls. Positive correlation between AGE and VEGF was found in patients with diabetic retinopathy sufficiently treated with retinal photocoagulation (r = 0.44, p<0.05), but not in those who were insufficiently treated (r = 0.26, p = 0.18). The present observations suggest that AGE may induce VEGF expression in an ischaemia-independent mechanism. AGE could be one of the important determinants of VEGF in diabetic retinopathy without obvious ischaemic regions.
Vascular endothelial growth factor (VEGF) elicits retinal vascular hyperpermeability, thrombosis and angiogenesis, having a central role in the pathogenesis of diabetic retinopathy.1 Furthermore, vitreous VEGF levels are increased in proliferative diabetic retinopathy, whereas the levels are decreased after treatment with …
Funding: This work was supported in part by Grants of Venture Research and Development Centers from the Ministry of Education, Culture, Sports, Science and Technology, Japan (SY), and the Specific Research Fund of Hokuriku University, Japan (MT).
Competing interests: None declared.