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Multifocal visual-evoked potential in unilateral compressive optic neuropathy
  1. Linda Semela1,
  2. E Bo Yang2,
  3. Thomas R Hedges1,
  4. Laurel Vuong1,
  5. Jeffery G Odel3,
  6. Donald C Hood2
  1. 1New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, Massachusetts, USA
  2. 2Department of Psychology, Columbia University, New York, New York, USA
  3. 3Department of Ophthalmology, Harkness Eye Institute, Columbia University, New York, New York, USA
  1. Correspondence to: Professor T R Hedges New England Eye Center, 750 Washington Street, Box 450, Boston, MA 02111, USA;thedges{at}


Aim: To evaluate the effects of unilateral compressive optic neuropathy on amplitude and latency of multifocal visual evoked potentials (mfVEPs).

Methods: Static automated perimetry and mfVEP recordings were obtained from six patients with presumed meningiomas affecting one optic nerve. Monocular and interocular amplitude and latency analyses were performed and compared with normal control subjects.

Results: The change in the mfVEP amplitude agreed with visual field findings with regard to topography and severity of deviation from normal. The delay in recordable responses from affected eyes ranged from 7.6 to 20.7 ms (interocular analysis) and 7.9 to 13.9 ms (monocular analysis).

Conclusions: Compressive optic neuropathy decreases the amplitude and increases the latency of the mfVEP. The changes in latency were similar to those seen in optic neuritis but larger than those in ischaemic optic neuropathy and glaucoma.

  • mfVEP, multifocal visual evoked potential
  • RMS, root mean square
  • SAP, static automated perimetry

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  • Published Online First 31 October 2006

  • Funding: This study was financially supported by the Swiss National Science Foundation Grant # PBBEB 104452.

  • Competing interests: None declared.

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