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  • Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population

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Laboratory science - Extended reports
Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population
  1. Mustafa Ünal1,
  2. Mehmet Güven2,
  3. Kazım Devranoğlu3,
  4. Ahmet Özaydın2,
  5. Bahadır Batar2,
  6. Nevbahar Tamçelik3,
  7. Ebru Eroğlu Görgün3,
  8. Didar Uçar3,
  9. Ahmet Sarıcı3
  1. 1Department of Ophthalmology, Akdeniz University Medical Faculty, Antalya, Turkey
  2. 2Department of Medical Biology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
  3. 3Department of Ophthalmology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
  1. Correspondence to: M Ünal Demircikara mah, 1426 sk Zeybek apt, B blok No14/12, Muratpaşa/Antalya, Turkey; mustafaunalmd{at}gmail.com

Abstract

Background: Genetic factors and oxidative damage have been shown to have a role in the development of primary open angle glaucoma (POAG).

Aim: To determine the effects of genetic polymorphisms of glutathione S transferase (GST)M1 and GSTT1 on the risk of POAG in a Turkish population.

Methods: Using a multiplex polymerase chain reaction (PCR), GSTM1 and GSTT1 gene polymorphisms were analysed in 144 patients with POAG and in 121 otherwise healthy controls of similar age.

Results: The GSTM1 positive genotype and the GSTT1 null genotype had an increased risk of developing POAG (p<0.001, OR 2.93, 95% CI 1.66 to 5.20 and OR 4.25, 95% CI 2.30 to 7.80, respectively). The risk of glaucoma also increased significantly in subjects with a combination of GSTM1 positive and GSTT1 null genotypes (p<0.001, OR 3.46, 95% CI 1.64 to 7.38).

Conclusion: The GSTM1 positive genotype and GSTT1 null genotype or the combination of both may be associated with the increased risk of development of POAG in the Turkish population.

  • GHT, glaucoma hemifield test
  • GST, glutathione S transferase
  • IOP, intraocular pressure
  • PCR, polymerase chain reaction
  • POAG, primary open-angle glaucoma
  • ROS, reactive oxygen species

https://doi.org/10.1136/bjo.2006.102418

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    Footnotes

    • Published Online First 14 September 2006

    • Competing interests: None declared.