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Levels of bimatoprost acid in the aqueous humour after bimatoprost treatment of patients with cataract
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  • Published on:
    Authors' response: Mechanism of action of bimatoprost.
    • Louis B. Cantor, Jay C. and Lucile L. Kahn Professor of Glaucoma Research and Education

    Dear Editor,

    We thank Dr. Camras for his interest in our report on levels of bimatoprost and its free acid in the aqueous humour of cataract patients after a single topical dose of bimatoprost [1] and welcome the opportunity to respond to his comments. We are in agreement with Dr. Camras that the results of our study [1] and those of his previously reported study [2] are similar, showing low nanomolar concentrat...

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    Conflict of Interest:
    None declared.
  • Published on:
    Bimatoprost, the prodrug of a prostaglandin analog
    • Carl B Camras, Professor and Chair, Department of Ophthalmology and Visual Sciences
    • Other Contributors:
      • Najam Sharif, Martin Wax, Johan Stjernschantz

    Dear Editor,

    We congratulate the authors of their adequately designed study(1) that demonstrates the high concentration of the free acid (the product of hydrolysis) of bimatoprost (BP), an amide, in the aqueous humor of patients receiving a single drop of BP 1, 3, or 6 hours prior to cataract surgery. This important study confirms the results found in previous studies.(2,3) However, despite providing important confirmat...

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    Conflict of Interest:
    None declared.