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  • Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis

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Clinical science
Scientific reports
Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis
  1. Yumiko Yoshida1,
  2. Sho-ichi Yamagishi2,
  3. Takanori Matsui2,
  4. Kazuo Nakamura2,
  5. Tsutomu Imaizumi2,
  6. Koichi Yoshimura1,
  7. Ryoji Yamakawa1
  1. 1Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan
  2. 2Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume, Japan
  1. Correspondence to: Dr S Yamagishi Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan; shoichi{at}med.kurume-u.ac.jp

Abstract

Aim: To evaluate whether aqueous humour levels of pigment epithelium-derived factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis.

Methods: Aqueous humour levels of MCP-1 and PEDF were determined by ELISA in 34 uveitis samples and 9 cataract control samples.

Results: Aqueous humour MCP-1 and PEDF levels were significantly higher in patients with infectious or non-infectious uveitis than in controls (mean (SD) 32.3 (10.7) ng/ml vs 4.48 (1.10) ng/ml vs 0.47 (0.10) ng/ml, and 8.40 (1.30) μg/ml vs 5.01 (0.92) μg/ml vs 1.32 (0.22) μg/ml, respectively, p<0.001). A positive correlation between PEDF and MCP-1 was found in patients with uveitis (r = 0.39, p<0.01).

Conclusion: The results demonstrated that aqueous humour levels of PEDF were positively associated with MCP-1 in patients with uveitis. The present observations suggest that aqueous humour levels of PEDF may be a marker of inflammation in uveitis.

  • MCP-1, monocyte chemoattractant protein-1
  • PEDF, pigment epithelium-derived factor

http://dx.doi.org/10.1136/bjo.2006.109843

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    Footnotes

    • Published Online First 13 December 2006

    • Competing interests: None declared.