Article Text

Download PDFPDF
Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis


Aim: To evaluate whether aqueous humour levels of pigment epithelium-derived factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis.

Methods: Aqueous humour levels of MCP-1 and PEDF were determined by ELISA in 34 uveitis samples and 9 cataract control samples.

Results: Aqueous humour MCP-1 and PEDF levels were significantly higher in patients with infectious or non-infectious uveitis than in controls (mean (SD) 32.3 (10.7) ng/ml vs 4.48 (1.10) ng/ml vs 0.47 (0.10) ng/ml, and 8.40 (1.30) μg/ml vs 5.01 (0.92) μg/ml vs 1.32 (0.22) μg/ml, respectively, p<0.001). A positive correlation between PEDF and MCP-1 was found in patients with uveitis (r = 0.39, p<0.01).

Conclusion: The results demonstrated that aqueous humour levels of PEDF were positively associated with MCP-1 in patients with uveitis. The present observations suggest that aqueous humour levels of PEDF may be a marker of inflammation in uveitis.

  • MCP-1, monocyte chemoattractant protein-1
  • PEDF, pigment epithelium-derived factor

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.