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Inhibition of experimental corneal neovascularisation by bevacizumab (Avastin)
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  • Published on:
    Use of Avastin in rat models: Comments.
    • Yuksel Totan, Department of Ophthalmology
    • Other Contributors:
      • Mesut Erdurmus

    Dear Editor

    We have read Manzano et al’s insightful paper[1] with interest and appreciated the comments concerning the inhibitory effects of bevacizumab on corneal neovascularisation (NV). However, the manuscript had some important aspects that need to be clarified. Cumulative data from numerous basic and clinical studies strongly implicates the central role of VEGF in ocular and corneal angiogenesis. Binding all free-ci...

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    Conflict of Interest:
    None declared.
  • Published on:
    Bevacizumab and rodent VEGF
    • Jing Hua, MD, postdoctoral research associate
    • Other Contributors:
      • Alex H. R. Varey, David O. Bates

    Dear Editor,

    We read with interest the recently published paper by Manzano et al. titled ‘Inhibition of experimental corneal neovascularisation by bevacizumab (Avastin)’. The authors used topical eyedrop application of either saline or bevacizumab in a rat model of corneal neovascularization, with apparent moderate success. Furthermore, in their discussion, they mention that there was incomplete inhibition of th...

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    Conflict of Interest:
    None declared.