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Ocular surface toxicity associated with topical interferon α-2b
  1. Anthony J Aldave,
  2. Anne Nguyen
  1. The Cornea Service, The Jules Stein Eye Institute, University of California Los Angeles Medical Center, Los Angeles, California, USA
  1. Correspondence to: Dr A J Aldave The Jules Stein Eye Institute, 100 Stein Plaza, UCLA, Los Angeles, CA 90095, USA; aldave{at}

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Conjunctival intraepithelial neoplasia (CIN) has traditionally been managed with surgical excision, combined with cryotherapy, with a wide range of reported recurrence rates.1 In cases of CIN that are too extensive to perform a complete surgical excision or in cases in which the surgical margins are involved, ophthalmologists are now using adjunctive topical antineoplastic agents such as mitomycin C2,3 and interferon α-2b (IFNα-2b)4,5,6,7,8,9,10,11,12 in place of, or in combination with, repeat surgical excision. Although the toxicity associated with the topical ophthalmic use of mitomycin C is well recognised,13–15 IFNα-2b has been reported not to cause ocular surface toxicity.4,5,6,7,8,9,10,11,12 We report a case of corneal toxicity, manifest as epithelial microcyst formation, associated with the use of topical IFNα-2b.

Case report

A 64-year-old man with a history of biopsy-proven CIN of the left eye presented to one of the authors (AJA) for evaluation. Twenty-two years earlier, he had undergone a superficial keratectomy and excision of a papillomatous conjunctival lesion from the left eye. Six years before presentation he had undergone a …

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  • Competing interests: None declared.