Article Text

Download PDFPDF
Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy
  1. Carine Biallosterski1,
  2. Mirjam E J van Velthoven1,
  3. Robert P J Michels2,
  4. Reinier O Schlingemann1,
  5. J Hans DeVries2,
  6. Frank D Verbraak1,3
  1. 1
    Department of Ophthalmology, Academic Medical Centre, Amsterdam, the Netherlands
  2. 2
    Department of Internal Medicine, Academic Medical Centre, Amsterdam, the Netherlands
  3. 3
    Laser Centre, Academic Medical Centre, Amsterdam, the Netherlands
  1. Frank D Verbraak, Department of Ophthalmology, Academic Medical Centre, PO Box 22660, Amsterdam, the Netherlands; f.d.verbraak{at}


Aim: A comparison of retinal thickness (RT) measurements with optical coherence tomography (OCT) in patients with type 1 diabetes mellitus (DM) and no or minimal diabetic retinopathy (DR) versus healthy controls.

Methods: Fifty-three patients with type 1 DM with no or minimal DR underwent full ophthalmic examination, fundus photography and OCT. Mean RT measured by OCT was calculated for the central fovea, the fovea, the pericentral and the peripheral area of the macula, and compared to healthy controls.

Results: Mean RT in the pericentral area was lower in patients with minimal DR (267 µm ± 20 µm; n = 23) compared to healthy controls (281 µm ±13 µm; p = 0.005; n = 28). Mean pericentral RT in patients without DR (276 µm ±14 µm; n = 30) was less than pericentral RT in healthy controls, but higher than in patients with minimal DR, without being statistically significant. None of the other regions showed a significant change.

Conclusion: In this study a significantly decreased pericentral RT was measured in patients with minimal DR compared to healthy controls. This could be explained by a loss of intraretinal neural tissue in the earliest stage of DR.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests: None.

  • Abbreviations:

    diabetes mellitus


    diabetic retinopathy


    optical coherence tomography


    retinal thickness


    thyroid stimulating hormone

Linked Articles

  • BJO at a glance
    Creig Hoyt