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Types of choroidal neovascularisation in newly diagnosed exudative age-related macular degeneration
  1. S Y Cohen1,
  2. C Creuzot-Garcher2,
  3. J Darmon3,
  4. T Desmettre4,
  5. J F Korobelnik5,
  6. F Levrat6,
  7. G Quentel1,
  8. S Paliès6,
  9. A Sanchez7,
  10. A Solesse de Gendre6,
  11. H Schluep6,
  12. M Weber8,
  13. C Delcourt9
  1. 1
    Centre Ophtalmologique d’Imagerie et de Laser, Paris, France
  2. 2
    Centre Hospitalier Universitaire, Dijon, France
  3. 3
    Centre d’Imagerie et de Laser, Nice, France
  4. 4
    Centre d’Imagerie et de Laser, Lambersart, France
  5. 5
    Centre Hospitalier Universitaire, Bordeaux, France
  6. 6
    Pfizer, Paris, France
  7. 7
    Biostatem Company, Nîmes, France
  8. 8
    Centre Hospitalier Universitaire, Nantes, France
  9. 9
    Inserm U593, Bordeaux, France; Université Victor Segalen, Bordeaux, France
  1. Salomon Y Cohen, Centre Ophtalmologique d’Imagerie et de Laser, 11 Rue Antoine Bourdelle, 75015 Paris, France; sycohen{at}


Aim: To describe the types and location of choroidal neovascularisation (CNV) in exudative age-related macular degeneration (AMD), including vascularised pigment epithelial detatchments (PED), and most recently described subtypes, such as retinal choroidal anasmostosis, also termed “retinal angiomatous proliferation” (RAP).

Methods: Prospective multicentre consecutive descriptive case series. A total of 207 consecutive cases of newly diagnosed exudative AMD undergoing fluorescein angiography (FA) were recruited by 7 French referral hospital-based or private centres. Indocyanine green angiography (ICG) also was performed, when judged necessary by investigators. Types and location of CNV were classified by two independent experts and adjudicated by a third when discordant.

Results: All patients had FA, while ICG was performed in 50% of subjects. A total of 17.6% had classic CNV only, 5.4% and 8.3% had predominantly and minimally classic CNV, respectively. Occult CNV could be classified in occult CNV without PED (32.7%) and occult CNV with PED, ie, vascularised PED (23.9%). RAP was observed in 15.1% of cases, and accounted for 30% of vascularised PED. In 5.8% of the cases there was haemorrhagic AMD and 4.8% had fibrovascular scars. Lesions were mainly subfoveal (80%). Agreement between the centre’s ophthalmologist and the final validated expert classification was moderate (κ = 0.52 for location and 0.59 for type of lesion).

Conclusion: This study confirms that newly diagnosed cases of exudative AMD are mainly occult and subfoveal. RAP appeared as a common lesion in patients with newly diagnosed exudative AMD.

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  • Competing interests: None declared.

  • SYC, CC-G, JD, CD, TD, JFK, GQ, MW and AS are consultants for Pfizer, France. HS, SP, ASdeG and FL are employees of Pfizer, France.

  • Abbreviations:

    age-related macular degeneration


    choroidal neovascularisation


    fluorescein angiography


    indocyanine green angiography


    pigment epithelial detatchments


    retinal angiomatous proliferation


    vascular endothelial growth factor