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Vasocentric fascicular uveal melanoma. Incidence and re-appraisal of the histological features
  1. I Pecorella1,
  2. P Grenga2,
  3. E M Vingolo2,
  4. A Ciardi1
  1. 1
    Department of Experimental Medicine and Pathology, University of Rome “La Sapienza”, Rome, Italy
  2. 2
    Department of Ophthalmologic Science, University of Rome “La Sapienza”, Rome, Italy
  1. Dr I Pecorella, Department of Experimental Medicine and Pathology, University of Rome “La Sapienza”, Viale Regina Elena, 324-00161 Rome, Italy; irene.pecorella{at}

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Malignant melanoma of the choroid is the most common intraocular tumour in the adults and usually offers few diagnostic difficulties on both clinical and histological examination. Uveal melanomas are composed of spindle and/or epithelioid cells, usually arranged in compactly woven bundles or distributed in a solid pattern. Far less common is the fascicular type, in which the tumour cells appear to be arranged either in palisades (Verocay-like pattern) or in columns perpendicular to a central blood vessel, the so-called vasocentric pattern. This sub-type of spindle-B cell melanoma was first described by Callender1 2 in 2.6% of 500 uveal melanomas, and an association with higher mortality was noted.1

We describe a case of fascicular malignant choroidal melanoma containing large areas of tumour cells arranged in a peculiar pseudopapillary pattern and discuss some of the cytological and immunohistochemical findings.

Case report

A 66-year-old woman complaining of progressive visual loss was referred to our Ophthalmologic Department after she was found to have a retinal detachment and a large non-pigmented choroidal tumour in the inferior-temporal quadrant of …

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  • Competing interests: None.