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Incidence and risk factors of retinopathy of prematurity in a tertiary eye hospital in Tehran
  1. R Karkhaneh1,
  2. S Z Mousavi1,
  3. M Riazi-Esfahani1,
  4. S A Ebrahimzadeh1,
  5. R Roohipoor1,
  6. M Kadivar2,
  7. L Ghalichi3,
  8. S F Mohammadi1,
  9. M R Mansouri1
  1. 1
    Eye Research Centre, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2
    Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3
    Department of Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  1. Professor R Karkhaneh, Pediatric Retina and Vitreous Division, Farabi Eye Hospital, Qazvin Square, South Kargar Street, Tehran 1336616351, Iran; karkhane{at}


Aim: To determine the incidence and risk factors of retinopathy of prematurity (ROP) in premature infants referred to a tertiary eye hospital during 2003–7 to provide preliminary evidence about ROP in Iran.

Methods: In a cross-sectional study, data for premature infants screened for ROP in Farabi Eye Hospital including possible risk factors and eye exams’ results were recorded and analysed using χ2, univariate and multiple regressions. Severe ROP was defined as ROP needing treatment or stage 4 or 5 of ROP.

Results: Among 953 premature infants, there were 329 (34.5%) different stages of ROP. Severe ROP was seen in 22.6% (215/953) of infants (16.5%: treatable, 6.1%: advanced untreatable). The mean gestational age (GA) and birth weight (BW) of infants with severe ROP were 28.8 (SD 2.4) weeks and 1256 (389) g respectively. Univariate analysis showed a significant relation between GA, BW, oxygen therapy, blood transfusion and ROP (p<0.001), while multiple-regression methods showed GA, BW and oxygen therapy as independent predictors of ROP (p<0.001, 0.019 and 0.033, respectively).

Conclusion: The authors observed a relatively high incidence of ROP in this series, especially its severe form affecting relatively more mature infants, which merits further investigation. GA, BW and oxygen therapy were independent ROP determinants.

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  • Funding: This research was funded by Tehran University of Medical Sciences (grant no 20499) as the thesis of SZM and SAE.

  • Competing interests: None.

  • Ethics approval: Ethics committee approval was obtained from The Faculty of Medicine of Tehran University of Medical Sciences.

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