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Original Article
The association between thyroid problems and glaucoma
  1. J M Cross1,
  2. C A Girkin1,
  3. C Owsley1,
  4. G McGwin, Jr1,2,3
  1. 1
    Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
  2. 2
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
  3. 3
    Section of Trauma, Burns, and Surgical Critical Care, Division of General Surgery, Department of Surgery, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
  1. Dr J M Cross, Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, 700 S 18th Street, Suite 609, Birmingham, AL 35294-0009, USA; jmcross{at}uab.edu

Abstract

Aims: To evaluate the association between thyroid problems and glaucoma.

Methods: A population-based cross-sectional sample with 12,376 participants from the 2002 National Health Interview Survey. Odds ratios (OR) and 95% confidence intervals (CIs) were used to quantify the association between a self-reported diagnosis of glaucoma and a self-reported history of thyroid problems, controlling for demographic characteristics and smoking status.

Results: The overall prevalence of glaucoma was 4.6%; 11.9% reported a history of thyroid problems. The prevalence of glaucoma among those who did and did not report thyroid problems was 6.5% and 4.4%, respectively (p = 0.0003). Following adjustment for differences in age, gender, race and smoking status, the association between glaucoma and thyroid problems remained (OR 1.38, 95% CI 1.08 to 1.76).

Conclusions: The results of this study lend support to the hypothesis that thyroid disorders may increase the risk of glaucoma. Research should continue evaluating potential mechanisms underlying this relationship and whether the treatment of thyroid problems reduces subsequent glaucoma risk.

https://doi.org/10.1136/bjo.2008.147165

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    Footnotes

    • Funding: National Institutes of Health grants R01-AG014684, P30-AG22838 and R21-EY14071, Research to Prevent Blindness, EyeSight Foundation of Alabama and the Alfreda J. Schueler Trust.

    • Competing interests: None.

    • Ethics approval: Ethics approval was provided by the Institutional Review Board of the University of Alabama at Birmingham.

    • Patient consent: Obtained.