Article Text

Download PDFPDF
High prevalence of glaucoma in Veli Brgud, Croatia, is caused by a dominantly inherited T377M mutation in the MYOC gene
  1. L Zgaga1,
  2. C Hayward2,
  3. Z Vatavuk3,
  4. G Bencic3,
  5. T Zemunik4,
  6. A Valkovic5,
  7. I Valkovic-Antic5,
  8. K Bucan4,6,
  9. I Rudan4,7,7
  1. 1
    Medical School, University of Zagreb, Zagreb, Croatia
  2. 2
    Human Genetics Unit, Medical Research Council, Edinburgh, UK
  3. 3
    University Hospital “Sestre Milosrdnice,” Zagreb, Croatia
  4. 4
    Croatian Centre for Global Health, Medical School, University of Split, Split, Croatia
  5. 5
    University Hospital Centre, Rijeka, Croatia
  6. 6
    Clinical Hospital Split, Split, Croatia
  7. 7
    Department of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, UK
  1. Dr L Zgaga, School of Public Health “Andrija Stampar,” Medical School, University of Zagreb, Croatia, Rockefellerova 4, 10000 Zagreb, Croatia; lina.zgaga{at}

Statistics from

An unusually high prevalence of early-onset open-angle glaucoma (OAG) in the population of Veli Brgud, Croatia, has been reported in previous studies.1 The most recent population census conducted in this isolated village in the mountains of Istrian peninsula (fig 1) reported a total of 550 inhabitants. Community-based ophthalmological examination was conducted during the 1990s among 536 inhabitants (97.5% of the total population) by the team of ophthalmologists from the University of Rijeka Medical School.1 OAG was diagnosed in 74 persons, and the population prevalence was found to be 13.8%. However, 67 (90%) of the affected individuals were linked to a single, large, nine-generation pedigree, while for the remaining seven persons with OAG, no link to the pedigree could be established. Although the village is isolated with high levels of inbreeding (proportion of consanguineous marriages is 22%), which usually favours the expression of recessive …

View Full Text


  • Funding: This study was supported by grants from (1) The Medical Research Council UK, (2) The Croatian Ministry of Science and Technology and (3) European Union Framework Program 6.

  • Competing interests: None.

  • Ethics approval: The study was granted ethical approval by the relevant Ethics Committee at the University of Zagreb Medical School.

  • Patient consent: Obtained.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.