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An unusually high prevalence of early-onset open-angle glaucoma (OAG) in the population of Veli Brgud, Croatia, has been reported in previous studies.1 The most recent population census conducted in this isolated village in the mountains of Istrian peninsula (fig 1) reported a total of 550 inhabitants. Community-based ophthalmological examination was conducted during the 1990s among 536 inhabitants (97.5% of the total population) by the team of ophthalmologists from the University of Rijeka Medical School.1 OAG was diagnosed in 74 persons, and the population prevalence was found to be 13.8%. However, 67 (90%) of the affected individuals were linked to a single, large, nine-generation pedigree, while for the remaining seven persons with OAG, no link to the pedigree could be established. Although the village is isolated with high levels of inbreeding (proportion of consanguineous marriages is 22%), which usually favours the expression of recessive …
Funding: This study was supported by grants from (1) The Medical Research Council UK, (2) The Croatian Ministry of Science and Technology and (3) European Union Framework Program 6.
Competing interests: None.
Ethics approval: The study was granted ethical approval by the relevant Ethics Committee at the University of Zagreb Medical School.
Patient consent: Obtained.
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