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The effects of photodynamic therapy on conjunctival in situ squamous cell carcinoma – a review of the histopathology
  1. K S Sears1,
  2. P R Rundle1,
  3. H S Mudhar2,
  4. I G Rennie1,3
  1. 1
    Ophthalmology Department, Royal Hallamshire Hospital, Sheffield, UK
  2. 2
    Histopathology Department, Royal Hallamshire Hospital, Sheffield, UK
  3. 3
    Academic Unit of Ophthalmology and Orthoptics, University of Sheffield, Sheffield, UK
  1. K Sears, Ophthalmology Department, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK; katherine.sears{at}

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We report the case of a 45-year-old lady who received photodynamic therapy (PDT) for a conjunctival neoplastic lesion. Unfortunately she was unable to complete the course of laser treatment and subsequently underwent excision of the lesion. Previously published papers have reported regression of conjunctival squamous cell carcinomas (SCC) with PDT, but this is the first case where regression of the neoplasm was confirmed with histopathological evidence.


A 45-year-old Afro-Caribbean lady presented with a 1-year history of a red left eye and a white spot on the medial aspect of the conjunctiva. She had no previous ophthalmic or medical history, and no history of trauma to the eye. On examination she had bilateral equal visual acuities of 6/9. Anterior segment examination of the left eye revealed a gelatinous 8 mm × 8 mm lesion of the medial conjunctiva. The lateral border showed a 5.5 mm × 5 mm white keratotic plaque overlying the medial limbus, with a vascularised corneal edge and feeder vessels medially (fig 1A). The lesion was suspected to be a conjunctival …

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  • Competing interests: None declared.