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The use of intravitreal Bevacizumab had been considered a first-line therapy in age-related macular degeneration (AMD) treatment until 2 years ago, despite the fact that there were no clinical trials backing it and that Bevacizumab was not created for that purpose. Consequently, Genentech modified the molecule of Bevacizumab, without affecting the basis of its efficacy but with the specific aim of treating this pathology, and so the new drug Ranibizumab was developed. However, no indirect comparisons have revealed any significant differences between both treatments in efficacy.1–3
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