Article Text

Download PDFPDF
Reversal of optic disc cupping in glaucoma
  1. M Harju,
  2. J Saari,
  3. L Kurvinen,
  4. E Vesti
  1. Helsinki University Eye Hospital, Helsinki, Finland
  1. Dr M Harju, Helsinki University Eye Hospital, Haartmaninkatu 4 C, PO Box 220, 00029 Hus, Finland; mika.harju{at}


Aim: To study whether reversal of optic disc cupping after intraocular pressure (IOP) reduction is related to risk of glaucoma progression.

Methods: In this prospective follow-up study, where 51 patients with exfoliation glaucoma and five with ocular hypertension combined with exfoliation syndrome were followed for 6 years after IOP reduction, 24 showed progression of glaucoma in visual fields or optic nerve head (ONH) stereophotographs. ONH topography was measured with the Heidelberg Retina Tomograph (HRT). A decrease in HRT parameter cup volume of more than 5% was considered cup reversal. Multiple logistic regression was used to model progression of glaucoma.

Results: Cup reversal (OR 0.226; 95% CI 0.055 to 0.918, p = 0.037), final IOP (OR 1.216; 95% CI 1.000 to 1.479, p = 0.050) and visual field mean defect at entry (OR 1.158; 95% CI 1.034 to 1.296, p = 0.011) were associated with progression. IOP change from study entry to 6-year control visit was not associated with progression (OR 0.964, 95% CI 0.850 to 1.092, p = 0.56).

Conclusion: Cup reversal seemed to be an independent protective factor for progression of glaucoma.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding: Financial support was provided by Silmäsäätiö (The Eye Foundation), Mary och C. Ehrnrooths Stiftelse and Glaukooma tukisäätiö LUX (the Glaucoma Foundation LUX).

  • Competing interests: None.

  • Ethics approval: The procedures followed the tenets of the Declaration of Helsinki and were approved by the Helsinki University Eye Hospital Ethics Committee.

  • Patient consent: Patient consent was obtained.