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Eighteen-month follow-up of intravitreal bevacizumab in type 2 idiopathic macular telangiectasia
  1. P Charbel Issa,
  2. R P Finger,
  3. F G Holz,
  4. H P N Scholl
  1. Department of Ophthalmology, University of Bonn, Bonn, Germany
  1. Dr H P N Scholl, Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str 2, D-53127 Bonn, Germany; hendrik.scholl{at}


Aim: To evaluate the effects of intravitreal bevacizumab for non-proliferative type 2 idiopathic macular telangiectasia (type 2 IMT) within a mean follow-up period of 18 months.

Methods: The authors retrospectively studied six eyes of five patients with type 2 IMT who received two doses of intravitreal bevacizumab (1.5 mg) at a 4-week interval, followed by further applications depending on disease activity. Examinations included biomicroscopy, standardised visual acuity (VA) testing, fluorescein angiography, retinal thickness analysis by optical coherence tomography and fundus-controlled microperimetry.

Results: Mean follow-up time was 18 months (range 16–21 months). The mean VA at four selected time points (1 month after second treatment, 1 month and 3–4 months after last treatment, and at last visit) increased significantly (by 8.8, 6.3, 7.7 and 8.7 Early Treatment Diabetic Retinopathy Study (ETDRS) letters, respectively; all p⩽0.05). Parafoveal leakage in fluorescein angiography and mean central retinal thickness decreased in all eyes following treatment. A rebound effect was observed after 3–4 months, and at the last visit, retinal thickness was increased in selected retinal sectors including the fellow eye.

Conclusion: Inhibition of vascular endothelial growth factor (VEGF) by intravitreally injected bevacizumab may lead to functional improvement as well as a transient decrease in leakage and retinal thickness in patients with type 2 IMT. A VEGF-mediated active disease stage in which treatment might be most effective is discussed.

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  • Funding: Supported by The Macular Telangiectasia Project (, DFG Heisenberg fellowship SCHO 734/2-1; EU FP6, Integrated Project “EVI-GENORET” (LSHG-CT-2005-512036).

  • Competing interests: None.

  • Ethics approval: Ethics approval was not required.

  • Patient consent: Informed consent was obtained from every patient.

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