You are here

Article Text

Article menu
Download PDFPDF
Letter
False negative antibody-based HLA-A29 typing in two patients with birdshot chorioretinopathy
  1. J D Wender,
  2. A D Fu,
  3. J M Jumper,
  4. H R McDonald,
  5. R N Johnson,
  6. E T Cunningham, Jr
  1. The San Francisco Retinal Foundation, and The Pacific Vision Foundation, California Pacific Medical Center, San Francisco, CA, USA
  1. Dr E T Cunningham, Jr, West Coast Retina Medical Group, 185 Berry Street, San Francisco, CA 94107, USA; emmett_cunningham{at}yahoo.com

https://doi.org/10.1136/bjo.2007.125666

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    A strong association between birdshot chorioretinopathy and HLA-A29 expression has been well established.1 In fact, some have suggested that HLA-A29 expression is essential to make the diagnosis of birdshot chorioretinopathy. Such a strong association makes accurate HLA-A29 subtyping quite important in patients suspected of having this entity. Herein, we describe two patients with birdshot chorioretinopathy in whom initial testing for HLA-A29 expression using antibody-based methods was negative and subsequent testing using more sensitive and specific PCR-based techniques was positive.

    Case 1

    A 45-year-old Caucasian man with a history of psoriatic skin lesions presented with worsening vision, floaters, and nyctalopia affecting both eyes for 2 months prior to presentation. Best corrected visual acuity was 20/25 …

    View Full Text

    Footnotes

    • Funding: Supported in part by The San Francisco Retinal Foundation and The Pacific Vision Foundation.

    • Competing interests: None declared.

    • Patient consent: Obtained.