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Shifting of the proliferative vitreoretinopathy milieu after tamponade with heavy silicone oil in eyes prone to proliferative vitreoretinopathy and bleeding
  1. A M Joussen1,
  2. A Lux1,
  3. B Kirchhof2
  1. 1
    Department of Ophthalmology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
  2. 2
    Department of Vitreoretinal Surgery, Center of Ophthalmology, University of Cologne, Cologne, Germany
  1. Dr A M Joussen, Department of Ophthalmology, Heinrich Heine University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany; joussena{at}

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Proliferative vitreoretinopathy (PVR) is the most important reason for blindness following retinal detachment. Presently, standard vitreous tamponades, lighter than water, only insufficiently support the inferior retina. A heavier-than-water tamponade displaces the inflammatory and PVR-stimulating environment to the superior part of the vitreous cavity. From the available data, high-density silicone oil (Densiron 68 68), a mixture of F6H8 with 5000cSt silicone oil, seems to be a therapeutic option, at least in selected patients with complex inferior retinal redetachments, where standard procedures already failed.13 The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) was designed to answer the question in a randomised trial whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina.4 This trial is ongoing.

While the current data indicate that a heavier-than-water tamponade may successfully seal inferior holes, there …

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