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Low prevalence of juvenile-onset Behçet’s disease with uveitis in East/South Asian people
  1. N Kitaichi1,
  2. A Miyazaki1,
  3. M R Stanford2,
  4. D Iwata1,
  5. H Chams3,
  6. S Ohno1,4
  1. 1
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  2. 2
    King’s College London, London, UK
  3. 3
    Behçet’s Research Center, Shariati Hospital, Teheran University for Medical Sciences, Teheran, Iran
  4. 4
    Department of Ocular Inflammation and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  1. Correspondence to Dr N Kitaichi, Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan; nobukita{at}


Aim: There is little information on the demographic and clinical characteristics of Behçet’s disease in children in different parts of the world. We sought to provide this information through a questionnaire survey of specialist eye centres.

Methods: Descriptive questionnaires were collected from 25 eye centres in 14 countries. The questionnaire surveyed details of juvenile-onset Behçet’s disease with uveitis. Ethnic groups, clinical features, treatments and prognosis of paediatric-age Behçet’s disease were examined on a worldwide scale.

Results: The clinical data of 135 juvenile-onset and 1227 adult-onset patients with uveitis were collected. The average age of disease diagnosis in the children was 11.7 years old. Of the ethnic groups identified 54% were from Middle East, 43% from Europe, but only 2% from East/South Asian countries. By contrast, 19.2% of adult patients were from East or South Asia. The frequency of genital ulcers in juvenile patients was 38.7%, which was significantly lower than in adult cases (53.5%; p<0.01).

Conclusions: Behçet’s disease with uveitis was less common in children than in adults in East/South Asia. Although the clinical features of the systemic disease were similar in children and adults, there was a lower frequency of genital ulceration in children.

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  • Funding This study was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) Japan, and the Ministry of Health, Labor and Welfare Japan.

  • Competing interests None declared.

  • Provenance and Peer review Not commissioned; externally peer reviewed.

  • Ethics approval Ethics approval was obtained from the Institutional Review Board of Hokkaido University Hospital for Clinical Research (#009-0065).

  • Patient consent Obtained.