Aim: To compare the long-term intraocular pressure (IOP) outcomes of Ahmed Glaucoma Valve (AGV) implantation to trabeculectomy with mitomycin C (MMC) in open-angle glaucoma (OAG).
Methods: 78 OAG patients who underwent AGV implantation were matched with respect to age, preoperative surgery, preoperative IOP and preoperative medicines to 88 OAG patients who underwent trabeculectomy with MMC with a minimum of 3 years’ follow-up. The cumulative probability of success between the two groups with different criteria was analysed: (1) an IOP⩽21 mm Hg and a reduction of IOP⩾15% from baseline; and (2) an IOP⩽18 mm Hg and a reduction of IOP⩾20% from baseline. No loss of light perception, no additional glaucoma surgery and no hypotony were also required.
Results: The 5-year cumulative probability of success was not statistically significant between eyes that had an AGV or trabeculectomy with MMC when success was defined as criteria A (p = 0.094). However, when success was defined according to criteria B, eyes undergoing trabeculectomy with MMC had a higher rate of success (p = 0.024).
Conclusions: Trabeculectomy with MMC has a significantly higher 5-year cumulative probability of success compared with AGV implants when greater reduction IOP is necessary.
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Funding Supported in part by an unrestricted grant from Research to Prevent Blindness. The authors also received support from D May II, E Kelton and L Kelton.
Competing interests None.
Provenance and Peer review Not commissioned; externally peer reviewed.
Ethics approval Ethics approval was provided by the Human Subject Protection Committee at the University of California, Los Angeles.
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