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Choroidal vascular hypofluorescence in indocyanine green angiography of high myopia
  1. K Sayanagi,
  2. Y Ikuno,
  3. K Soga,
  4. T Wakabayashi,
  5. M Tsujikawa,
  6. Y Tano
  1. Department of Ophthalmology, Osaka University Medical School, Yamadaoka, Osaka, Japan
  1. Correspondence to Dr Y Ikuno, Department of Ophthalmology E7, Osaka University Medical School, 2-2 Yamadaoka, Suita 565-0871, Japan; ikuno{at}

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The choroidal circulation in high myopia decreases in conjunction with ocular enlargement experimentally and clinically.1 2 Using indocyanine green angiography (ICGA), investigators have reported narrowing and loss of the large choroidal vessels during the follow-up period.3 4 ICGA is a useful diagnostic tool with which to observe the choroidal circulation, and Heidelberg retina angiography 2 (HRA2; Heidelberg Engineering, Heidelberg, Germany) is a confocal laser scanning system that provides a higher resolution of ICGA compared with the conventional fundus camera. In the current study, we report a new finding of choroidal vasculature seen on HRA2-ICGA.

Case reports

Case 1

A 78-year-old woman had myopic choroidal neovascularization (mCNV) in her right eye. The best-corrected visual acuity (BCVA) was 20/40. The axial length was 27.93 mm. Fluorescein angiography (FA) and fundus photography showed subfoveal choroidal neovascularization (CNV) and several patchy atrophies. Early-phase HRA2-ICGA showed a filling delay, and late-phase HRA2-ICGA showed several linear hypofluorescences that corresponded exactly with the choroidal vessels that were perfused in the early. Conventional ICGA did not detect linear hypofluorescence (figs 1A–D, 2).

Figure 1

HRA2-indocyanine green angiography (ICGA), conventional ICGA, fluorescein angiography (FA) and fundus photography from case 1. (A) Early-phase HRA2-ICGA showing normal choroidal circulation (arrows) except for a localized filling delay at the macula. An area of …

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  • Funding Supported by grant No 16591750 from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.