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Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration
  1. K Yi1,2,3,
  2. M Mujat1,4,5,
  3. B H Park1,4,
  4. W Sun4,6,
  5. J W Miller1,7,
  6. J M Seddon8,
  7. L H Young1,7,
  8. J F de Boer1,4,9,
  9. T C Chen1,2
  1. 1
    Harvard Medical School, Boston, Massachusetts, USA
  2. 2
    Massachusetts Eye and Ear Infirmary, Glaucoma Service, Boston, Massachusetts, USA
  3. 3
    Kangnam Sacred Heart Hospital, Hallym University, Seoul, Korea
  4. 4
    Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts, USA
  5. 5
    Physical Sciences Inc., Andover, Massachusetts, USA
  6. 6
    Boston University, Department of Physics, Boston, Massachusetts, USA
  7. 7
    Massachusetts Eye and Ear Infirmary, Retina Service, Boston, Massachusetts, USA
  8. 8
    Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
  9. 9
    Department of Physics and Astronomy, VU University, Amsterdam, The Netherlands
  1. Dr T C Chen, Glaucoma Service, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA; teresa_chen{at}


Background/aims: To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomical changes in eyes with non-neovascular age-related macular degeneration (AMD) compared with time domain optical coherence tomography (TDOCT).

Methods: Images were obtained from three eyes of three patients with AMD using an experimental SDOCT system. Both a titanium–sapphire (Ti:sapphire) laser and a superluminescent diode (SLD) were used as a broadband light source to achieve cross-sectional images of the retina. A qualitative and quantitative analysis was performed for structural changes associated with non-neovascular AMD. An automated algorithm was developed to analyse drusen area and volume from SDOCT images. TDOCT was performed using the fast macular scan (StratusOCT, Carl Zeiss Meditec, Dublin, California).

Results: SDOCT images can demonstrate structural changes associated with non-neovascular AMD. A new SDOCT algorithm can determine drusen area, drusen volume and proportion of drusen.

Conclusions: With new algorithms to determine drusen area and volume and its unprecedented simultaneous ultra-high speed ultra-high resolution imaging, SDOCT can improve the evaluation of structural abnormalities in non-neovascular AMD.

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  • Funding: This paper was partially supported by the National Institutes of Health, Bethesda, Maryland (RO1EY014975, R01-RR19768). Nidek sponsors JFB’s research. Patents in spectral domain optical coherence tomography: JFB, MM, BHP.

  • Competing interests: None.

  • Ethics approval: Ethics approval was provided by the Massachusetts Eye and Ear Infirmary and Massachusetts General Hospital Institutional Review Boards.

  • Patient consent: Obtained.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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