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Amantadine HCl is an antiviral agent used to treat and prevent influenza A. It is also indicated for the treatment of Parkinsonism and drug-induced extrapyramidal symptoms. Off-label uses include multiple sclerosis, Alzheimer disease and attention-deficit/hyperactivity disorder (ADHD). We report two patients with reversible, profound visual loss and corneal oedema associated with amantadine use.
A 12-year-old girl with generalised anxiety …
Funding: Unrestricted Grant from Research to Prevent Blindness, New York and the Minnesota Lions.
Competing interests: None.
Ethics approval: Ethics approval was provided by the Institutional Review Board at the University of Minnesota.
Patient consent: Obtained from the patient/parents.