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Intraocular pressure control and fluctuation: the effect of treatment with selective laser trabeculoplasty
  1. M Nagar,
  2. E Luhishi,
  3. N Shah
  1. Clayton Hospital, The Mid Yorkshire Hospitals NHS Trust, Northgate, Wakefield, UK
  1. Ms M Nagar, Clayton Hospital, The Mid Yorkshire Hospitals NHS Trust, 1 Woodthorpe Park Drive, Sandal, Northgate, Wakefield WF2 6HY, UK; madhunagar{at}


Aims: To evaluate the effect of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) control and diurnal tension curves of patients with open-angle glaucoma (OAG) and ocular hypertension (OHT), and to compare this effect with that of latanoprost.

Methods: Forty patients were randomised to receive either SLT or latanoprost. IOP control was evaluated by comparing pretreatment values with post-treatment measurements on day 3, week 1, month 1 and 4–6 months; success was defined as 20% decrease in IOP. Tension curves were plotted prior to treatment and 4–6 months afterwards; success was 50% reduction in fluctuation.

Results: SLT decreased pressure by 4.7 mm Hg on average (95% CI 3.6 to 5.7 mm Hg; p<0.01). The reduction was similar for latanoprost at all follow-ups except month 1; 75% of SLT patients and 73% of latanoprost patients achieved success in IOP control (p = 0.4). SLT significantly reduced IOP fluctuation, but latanoprost was more effective (3.6 mm Hg, 95% CI 3.2 to 3.9 mm Hg vs 2.5 mm Hg, 95% CI 2.2 to 2.9 mm Hg for SLT; p = 0.04). Success in fluctuation reduction was 50% for SLT and 83% for latanoprost (p = 0.045).

Conclusions: Both SLT and latanoprost had a significant impact on IOP control and fluctuation. While latanoprost may be more likely to reduce IOP fluctuation, SLT has the benefit of being a one-time intervention not requiring ongoing patient compliance.

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  • Competing interests: None.

  • Ethics approval: Ethics approval was provided by the Research and Ethics Committee, Pinderfields & Pontefract NHS trust.

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