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Humphrey matrix frequency doubling perimetry for detection of visual-field defects in open-angle glaucoma
  1. C I Clement1,2,
  2. I Goldberg1,2,3,
  3. P R Healey2,3,4,
  4. S Graham2,3
  1. 1
    Sydney Eye Hospital, Sydney, Australia
  2. 2
    Eye Associates, Sydney, Australia
  3. 3
    The University of Sydney, Sydney, Australia
  4. 4
    Millennium Institute, Westmead Hospital, Sydney, Australia
  1. Dr C Clement, Level 4, 187 Macquarie Street, Sydney, NSW 2000, Australia; colinc1{at}


Aim: Matrix perimetry uses frequency-doubling technology (FDT) incorporated into a 5° test target. This permits testing of the same number of locations within a defined visual field as standard automated perimetry (SAP) and may improve performance compared with original FDT perimetry. This study investigates the performance of Humphrey Matrix perimetry for detecting glaucomatous visual-field loss.

Design: Prospective case control study.

Methods: We recruited 115 participants with glaucomatous visual-field loss and 33 normal controls from an urban glaucoma practice. Each participant performed SITA 24-2 SAP then threshold 24-2 Matrix perimetry. Severity of visual-field loss was defined using SAP mean deviation (MD) as early (MD >−6 dB), moderate (MD −6 to −12 dB) or advanced (MD <−12 dB). The sensitivity and specificity of Humphrey Matrix perimetry were calculated for different automated indices.

Results: The matrix perimetry sensitivity and specificity were up to 100% for moderate and advanced glaucomatous visual-field loss. A receiver operator characteristic area under the curve (AUC) analysis revealed MD to be slightly better than pattern standard deviation (PSD) for defining moderate (AUC: MD 0.997; PSD 0.987) and advanced defects (AUC: MD 1.000; PSD 0.987). Matrix was less sensitive (up to 87.3%) for detecting early glaucomatous visual-field loss compared with SITA 24-2 SAP (AUC: PSD 0.948; MD 0.910).

Conclusions: Matrix perimetry is excellent for detection of moderate to advanced glaucomatous visual-field loss but may miss some early defects. It may be well suited to following progression of early to moderate field loss because of a smaller target size compared with original FDT perimetry.

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  • Competing interests: None.

  • Ethics approval: Ethics approval was provided by South East Sydney Area Health Service human research ethics committee.

  • Patient consent: Obtained.