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Searching for intraocular antibody production against Parvovirus B19, Mumps virus and Measles virus in patients with intermediate and posterior uveitis
  1. N Visser1,2,
  2. A Rothova2,
  3. J D F de Groot-Mijnes1,
  4. L de Visser1,2
  1. 1
    Department of Virology, University Medical Center Utrecht, The Netherlands
  2. 2
    FC Donders Institute of Ophthalmology, University Medical Center Utrecht, The Netherlands
  1. Ms L de Visser, Department of Virology, University Medical Center Utrecht, Heidelberglaan 100, Rm G04.614, 3584 CX Utrecht, The Netherlands; l.devisser-6{at}

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Uveitis is a destructive ocular inflammation and is caused by either infectious agents or non-infectious immune reactions. The aetiology is still unknown in about 50% of the patients. The distinction between an infectious and non-infectious aetiology is crucial for treatment and prognosis. The main infectious agents in the West include Toxoplasma gondii, Herpes simplex virus (HSV), Varicella zoster virus (VZV), Cytomegalovirus (CMV) and Rubella virus, pathogens which are also the most frequent causes of congenital and childhood infections. Several case reports have mentioned uveitis following Parvovirus, Mumps or Measles infection.13 Despite the MMR-vaccination programme, Mumps and Measles outbreaks continue to occur.4 We hypothesised that other common viral childhood infections might also be able to incite uveitis and selected Parvovirus B19, Mumps virus and Measles virus as the most likely …

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  • Competing interests: None.

  • Funding: This study was supported by the Dr FP Fischer Foundation, Amersfoort, The Netherlands (Lenneke de Visser) and sponsored by the Foundation for Dutch Ophthalmologic Research (SNOO), Rotterdam, The Netherlands (Lenneke de Visser).