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Promise and potential pitfalls of anti-VEGF drugs in retinopathy of prematurity
  1. B A Darlow1,
  2. C Gilbert2,
  3. G E Quinn3,
  4. R Azad4,
  5. A L Ells5,
  6. A Fielder6,
  7. A Zin7
  1. 1
    Department of Paediatrics,University of Otago, Christchurch. Christchurch, New Zealand
  2. 2
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK
  3. 3
    The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
  4. 4
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India
  5. 5
    Calgary Retina Consultants, Calgary, Alberta, Canada
  6. 6
    Department of Optometry & Visual Science, City University, London, UK
  7. 7
    Instituto Fernandes Figuera, FIOCRUZ, Rio de Janeiro, Brazil
  1. Professor B Darlow, Christchurch School of Medicine, University of Otago Christchurch, PO Box 4345, Christchurch 8140, New Zealand; brian.darlow{at}otago.ac.nz

https://doi.org/10.1136/bjo.2008.156208

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    Only rarely does a new treatment offer a real sea change. An example in the field of neonatology is the use of exogenous surfactant for hyaline membrane disease.1 For the eye, anti-vascular endothelial growth factor (VEGF) drugs may be the therapeutic advance of our time, revolutionising the treatment of vasoproliferative retinopathies including age-related macular degeneration and diabetic retinopathy. In his informative editorial, Sears suggests that anti-VEGF therapy may play a similar role in retinopathy of prematurity.2

    Retinopathy of prematurity (ROP) is a vasoproliferative disease, and it is therefore not surprising that there is increasing enthusiasm for anti-VEGF drugs.3 4 …

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