Article Text

Download PDFPDF
Clinical science
Incidence of early-onset glaucoma after infant cataract extraction with and without intraocular lens implantation
  1. I B Y Wong1,2,
  2. V D Sukthankar1,
  3. M Cortina-Borja3,4,
  4. K K Nischal1,3
  1. 1
    Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children, London, UK
  2. 2
    Department of Ophthalmology, National University Health System, Singapore
  3. 3
    Ulverscroft Vision Research Group (UVRG), Institute of Child Health, London, UK
  4. 4
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
  1. Correspondence to Dr K K Nischal, Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK; kkn{at}


Aims: To determine the incidence of glaucoma, with onset within 1 year after the date of cataract surgery (early onset) performed in the first year of life, with or without intraocular lens (IOL) implantation.

Methods: A retrospective review of a single surgeon’s cohort from 1999 to 2006. Glaucoma onset risk, comparison of aphakic/pseudophakic eyes and IOL type were analysed together with microcornea, persistent fetal vasculature (PFV) and age ⩽4 weeks at surgery.

Results: Ninety-eight eyes (62 patients; mean age 2.88 months) were included with 61 eyes (36 patients) aphakic (57 planned and four failed implantations), and 37 eyes (26 patients) pseudophakic. At a mean follow-up of 2.51 years,15.3% (12.2% within 1 year) of all eyes, 9.8% of eyes (6.6% within 1 year) in the planned aphakic group, all four eyes with failed implantation and 13.5% of the pseudophakic eyes (10.8% within 1 year) developed glaucoma. Glaucoma incidence stratified by absence or presence of IOL showed no statistically significant difference, but eyes in the rigid polymethylmethacrylate group had an increased glaucoma risk compared with the Acrysof group (p = 0.002). Microcornea, PFV and age ⩽4 weeks at surgery were not significant predictors of early-onset glaucoma.

Conclusions: In this single surgeon study of infant cataract surgery only, age ⩽4 weeks at surgery was not a predictor of early-onset glaucoma. The rate of aphakic and pseudophakic early-onset glaucoma was not found to be statistically different, but we found a statistically different rate of glaucoma between the two IOL types which needs further evaluation, given that this is a retrospective review. Excessive surgical trauma influences incidence of glaucoma.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests None.

  • Provenance and Peer review Not commissioned; externally peer reviewed.

  • Ethics approval Ethics approval was provided by the Great Ormond Street Hospital for Children Institutional Review Board.