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Clinical science
Relationship between different fluorescein and indocyanine green angiography features in multiple evanescent white dot syndrome
  1. R dell’Omo,
  2. R Wong,
  3. M Marino,
  4. K Konstantopoulou,
  5. C Pavesio
  1. Medical Retina Department, Moorfields Eye Hospital, London, UK
  1. Correspondence to Mr C Pavesio, Medical Retina Department, Moorfields Eye Hospital, 162 City Road, London EC1V 2PD, UK; carlos.pavesio{at}


Objectives: To study the relationship between different fluorescein and indocyanine green angiographic features in a case series of multiple evanescent white dot syndrome (MEWDS) and to gain insight into its pathophysiological nature.

Methods: Retrospective review of seven patients (eight eyes) with MEWDS (selected based on clinical and angiographic manifestations of the disorder) examined using slit-lamp biomicroscopy and studied using fluorescein angiography (FA) and indocyanine green angiography (ICGA).

Results: In the clinically affected eyes, FA early phases revealed hyperfluorescence in three eyes and a combination of hyper- and hypofluorescence in five eyes; the following relationships between FA and ICGA were found: (1) areas of early hypo- and late hyperfluorescence (staining and leakage) on FA corresponding to areas of early hypo and late hypo-,iso or hyperfluorescence on ICGA; (2) early and late hyperfluorescence (staining but very faint, if any, leakage) on FA corresponding to normal early ICGA and intermediate-late hypofluorescence; (3) areas of hypo- and hyperfluorescence on ICGA without a clear counterpart on FA.

Conclusions: Angiographic features may vary in eyes with similar clinical signs of MEWDS. Such variability could reflect the different anatomical structures involved during the natural evolution of the disease. Angiographic studies suggest that both, inner and outer choroid, are involved in this disorder. The final outcome is not affected by the initial angiographic presentation.

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  • Competing interests None.

  • Ethics approval Ethics approval was provided by Moorfields Eye Hospital, NHS Foundation Trust.

  • Patient consent Obtained.

  • Provenance and Peer review Not commissioned; externally peer reviewed.