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Twenty-four-hour ocular perfusion pressure in primary open-angle glaucoma
  1. Vital P Costa1,
  2. Jesus Jimenez-Roman2,
  3. Felix Gil Carrasco2,
  4. Alvaro Lupinacci1,
  5. Alon Harris3
  1. 1Department of Ophthalmology, University of Campinas, Campinas, Brazil
  2. 2Department of Ophthalmology, Associacion para Evitar la Ceguera, Mexico City, Mexico
  3. 3Department of Ophthalmology, Indiana University, Indianapolis, Indiana, USA
  1. Correspondence to Dr Vital P Costa, Department of Ophthalmology, University of Campinas, Campinas, Rua Bahia, 1087 apto 21., São Paulo, SP 01244-001, Brazil; vp.costa{at}


Aim To compare the 24 h intraocular pressure (IOP), blood pressure (BP), and perfusion pressure (PP) of primary open-angle glaucoma (POAG) patients and healthy individuals.

Methods 24 healthy individuals and 29 POAG patients underwent IOP and BP measurements every 2 h, starting at 08:00 until 06:00 of the next morning. IOP measurements were made by a masked observer with a Goldmann tonometer at the slit-lamp from 08:00 to 22:00 and with the Perkins tonometer in supine position from 24:00 to 06:00. Systolic and diastolic BP (SBP and DBP) measurements were performed with an automated device.

Results Mean IOPs in POAG patients were significantly higher at all time intervals (p<0.001). The mean SBP was significantly higher in POAG patients from 04:00 to 10:00, and also at 14:00 and 18:00 (p<0.05). In POAG patients, the mean DBP was significantly higher at 08:00 and 10:00, but was significantly lower at 04:00 (p<0.05). In POAG patients, the mean systolic perfusion pressure (SPP) was significantly higher at 08:00 and 10:00 (p<0.01), whereas the mean diastolic perfusion pressure (DPP) was significantly lower from 24:00 to 06:00 (p<0.05).

Conclusion Although higher SPPs are observed in POAG patients during the morning, lower DPPs are found during the night.

  • Glaucoma
  • intraocular pressure
  • perfusion pressure
  • blood pressure
  • fluctuation
  • physiology

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  • Linked articles: 182527.

  • This study was presented in part at 2009 ARVO.

  • Funding Merck, Sharp & Dhome.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by the IRB Asociaion para Evitar la Ceguera.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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