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Clinical science
Effect of primary selective laser trabeculoplasty on tonographic outflow facility: a randomised clinical trial
  1. Saurabh Goyal1,
  2. Laura Beltran-Agullo1,
  3. Safina Rashid1,
  4. Shaheen P Shah2,
  5. Remin Nath1,
  6. Adanna Obi1,
  7. K Sheng Lim
  1. 1Department of Ophthalmology, St Thomas' Hospital, London, UK
  2. 2International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, UK
  1. Correspondence to Mr Kin Sheng Lim, Department of Ophthalmology, St Thomas' Hospital, Westminster Bridge Road SE1 7EH, London, UK; shenglim{at}gmail.com

Abstract

Purpose To investigate the effect of 180° versus 360° primary selective laser trabeculoplasty (SLT) on tonographic outflow facility and intraocular pressure (IOP).

Design Prospective, single masked randomised clinical trial.

Participants Patients with untreated primary open angle glaucoma or ocular hypertension both with IOP >21–35 mmHg.

Methods 40 patients randomly treated with 180° or 360° SLT after baseline tonographic outflow facility (electronic Schiøtz tonography) and IOP measurements were repeated after 1 month. One eye from each patient was randomly selected for analysis. Eight untreated eyes were included as a control group.

Main Outcome Measures Tonographic outflow facility and IOP difference. Responders were defined as having at least a 20% reduction in IOP.

Results Three patients were excluded due to poor tonography. There were 18 eyes in the 180° group and 19 eyes in the 360° group. Tonographic outflow facility increased significantly (180° p=0.003, 360° p=0.005) and IOP decreased significantly (180° and 360° p<0.001) from baseline. There were no significant differences between the two groups as regards the increase in tonographic outflow facility (180° group 37.5%, 360° group 41%, p=0.23) and decrease in IOP (180° group 24%, 360° group 35%, p=0.35). There were similar number of responders in 180° group (72%) as compared to 360° group (89.5%, p=0.23). Tonographic outflow facility and IOP did not change significantly from baseline in the control group (tonographic outflow facility: 8% increase p=0.48, IOP: 4% decrease p=0.33).

Conclusions Primary SLT significantly increased the tonographic outflow facility and decreased IOP in patients with primary open angle glaucoma and ocular hypertension but no statistically significant differences were found between the 360° and 180° groups. The level of IOP reduction due to primary SLT treatment could not be explained by the increase in tonographic outflow facility alone.

Clinical trial registration ISRCTN66330584, Current Controlled Trials. 1/11/2006

  • Aqueous humour
  • intraocular pressure
  • physiology
  • treatment lasers
  • clinical trial

https://doi.org/10.1136/bjo.2009.176024

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    Footnotes

    • Linked articles 182543.

    • Meeting Presentation, American Academy of Ophthalmology Annual Meeting, November 2008, Royal College of Ophthalmologists, Annual Meeting, May 2008.

    • Funding Financial Support Supported in part by the UK National Institute of Health Research (KSL).

    • Competing interests The SLT machine was provided by Ellex (NSW, Australia) on loan for the duration of the study. The sponsor or funding organisation had no role in the design or conduct of this research. Dr Lim and Dr Goyal have received travel grants from Ellex.

    • Patient consent Obtained.

    • Ethics approval This study was conducted with the approval of the St Thomas' Hospital Ethics Committee.

    • Provenance and peer review Not commissioned; externally peer reviewed.

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