Article Text

Download PDFPDF
Gender and laterality affect recurrences of acute anterior uveitis
  1. S Agnani1,
  2. D Choi2,
  3. T M Martin3,
  4. C R Austin3,
  5. J R Smith3,
  6. J R Lutt4,
  7. J T Rosenbaum3,4
  1. 1School of Medicine, Oregon Health & Science University, Portland, Oregon, USA
  2. 2Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, Oregon, USA
  3. 3Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, USA
  4. 4Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, Oregon, USA
  1. Correspondence to Shivali Agnani, School of Medicine, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239-3098, USA; agnanis{at}


Aim Acute anterior uveitis (AAU) associated with HLA-B27 or axial spondyloarthritis (axial SpA) is primarily unilateral and recurrent. We tested the hypotheses that disease laterality and gender affected recurrences of AAU.

Methods We studied 207 AAU subjects who were either HLA-B27 positive or had a verified history of axial SpA with documentation of the first uveitis episode. We recorded gender, laterality, duration, and time between episodes.

Results Of 207 subjects, 126 (60.9%) had axial spondyloarthritis. Of the 179 with known HLA-B27 status, 174 (97.2%) were HLA-B27 positive. The initial episode of AAU occurred slightly more often in the right eye, 109 (52.6%), than in the left, 91 (44.0%) or bilaterally, 7 (3.4%), but the difference between right and left was not significant (p=0.23). Interestingly, 69.4% of subsequent episodes occurred in the same eye affected previously (95% CI 59.3%, 78.3%, p=0.0001). In subjects with recurrent AAU, the probability of being disease-free for one year was 38.9% (95% CI 29.1%, 52.0%) using Kaplan-Meier estimates. Univariate analyses showed that male gender (p=0.03) and AAU which recurred in the same eye (p=0.04) was associated with a shorter time interval between episodes. Multivariate analysis by the Cox proportional hazards model showed similar results.

Conclusions The initial episode of unilateral AAU associated with HLA-B27 or axial SpA randomly affects either eye. Subsequent episodes occur more often in the same eye previously affected. Male gender and history of unilateral AAU in the same eye are associated with a shortened time interval between relapses.

  • Anterior chamber
  • inflammation
  • epidemiology

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding This study was supported in part by Research to Prevent Blindness, NIH R01 EY13139, NIH P30 EY010572, the Stan and Madelle Rosenfeld Family Trust, the William and Mary Bauman Foundation, and the Fund for Arthritis and Infectious Disease Research.

  • Competing interests None.

  • Ethics approval This study was conducted under institutional review board protocols approved at Oregon Health & Science University.

  • Provenance and peer review Not commissioned; externally peer reviewed.