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Soft drusen remodelling
Smith et al quantified the dynamic remodelling process of soft drusen resorption and new drusen formation in 20 patients with AMD. Each eye was imaged at baseline and at a mean interval of 2 years and images were precisely registered by an automated technique. The drusen were classified into three groups: new drusen (only in the final image), resorbed drusen (only in initial image), and stable drusen (present in both images). Absolute change in drusen as well as dynamic drusen activity was measured. Dynamic remodelling processes of drusen resorption and new drusen formation as distinct disease activities that can occur simultaneously that are not captured by change in total drusen load were observed. Dynamic changes may be a useful marker of disease activity. See page 1618
Assessing chloroquine toxicity with RNFL thickness, mERG, and visual field
Xiaoyun et al assessed chloroquine (CQ) toxicity by visual field testing (Humphrey 10-2 testing strategy), multifocal electroretinography (mfERG) and RNFL thickness (GDxVCC) in 60 patients with rheumatoid …
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