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Laboratory science
In vitro emulsification assessment of new silicone oils
  1. Albert Caramoy,
  2. Sabine Schröder,
  3. Sascha Fauser,
  4. Bernd Kirchhof
  1. Department of Vitreo-Retinal Surgery, University of Cologne, Center of Ophthalmology, Cologne, Germany
  1. Correspondence to Dr med Albert Caramoy, University of Cologne, Center of Ophthalmology, Department of Vitreo-Retinal Surgery, Kerpener Str. 62, Cologne 50924, Germany; acaramoy{at}


Aim To investigate whether the emulsification of conventional silicone oils can be reduced by adding small amounts of silicone molecules of a very long chain length.

Methods Siluron 1000, Siluron 2000, Siluron 5000, Acri.Sil-Ol 5000, Oxane 5700, Densiron 68 LV, Densiron 68 and Densiron 68 HV (0.5 ml) were each tested along with either plasma or serum (0.5 ml) in a glass cuvette. Emulsification was induced by sonication and documented by photography. The total area of emulsified oil was assessed using the ImageJ software.

Results The addition of small amounts of very-long-chain silicone molecules significantly reduced the emulsification for 1000 cSt silicone oil (Siluron 2000) and for 1000 cSt silicone oil with an admixture of F6H8 (Densiron 68 HV).

Conclusion New low-viscosity silicone oils show a reduced emulsification similar to that of 5000 cSt oils. In future, it may be possible to avoid using 5000 cSt oils. The findings may foster silicone oil surgery in general, and in particular the application of small-incision techniques.

  • Silicone oil
  • polydimethylsiloxane
  • emulsification
  • vitreous
  • treatment surgery

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: and

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  • Funding Supported in part by the Forschung für das Sehen eV.

  • Competing interests Materials, that is silicone oils, were provided by Fluoron GmbH, Neu-Ulm, Germany.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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