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Assessment of corneal biomechanical properties and intraocular pressure with the Ocular Response Analyzer in childhood myopia
  1. Pei-Yao Chang1,
  2. Shu-Wen Chang1,2,3,
  3. Jiun-Yi Wang4
  1. 1Department of Ophthalmology, Far Eastern Memorial Hospital, Ban-Chiao, Taipei, Taiwan
  2. 2Department of Medical Research, Far Eastern Memorial Hospital, Ban-Chiao, Taipei, Taiwan
  3. 3Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
  4. 4Department of Healthcare Administration, Asia University, Wufeng, Taichung, Taiwan
  1. Correspondence to Dr Shu-Wen Chang, Department of Medical Research and Ophthalmology, Far Eastern Memorial Hospital; Professor, Department of Ophthalmology, National Taiwan University Hospital, Taipei 110, Taiwan; swchang2007{at}


Background/aims The authors estimated the association between corneal biomechanical properties and axial length in myopic children and verified the relationship between axial length and intraocular pressure (IOP).

Methods This cross-sectional study included 126 eyes of 63 children, aged 12.02±3.19 years. Corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT) and IOP were recorded with the Reichert Ocular Response Analyzer. Axial length (AL) and anterior chamber depth (ACD) were measured by the IOLMaster, whereas corneal curvature was measured by an autorefractor.

Results In multivariable mixed model analysis, CH correlated significantly with AL (p<0.0001), ACD (p=0.044) and CCT (p<0.0001), but not with curvature; CRF correlated significantly with AL (p=0.004) and CCT (p<0.0001) but not ACD or curvature. The difference in CH between the two eyes of each patient correlated significantly with the difference in the AL between the two eyes (p=0.002). IOP did not correlate with age, gender or AL.

Conclusion Lower CH and CRF were associated with longer AL but not corneal curvature. The association between lower CH and deeper ACD demonstrated the importance of CH as a determinant of ocular biometry in both the anterior and posterior segments. Differences in corneal biomechanical properties may indicate more generalised structural differences between eyes.

  • Childhood myopia
  • corneal hysteresis
  • corneal biomechanical properties
  • cornea
  • optics and refraction
  • anatomy
  • physiology
  • imaging

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  • Funding This project was supported by Far Eastern Memorial Hospital grant: FEMH-97-C-038.

  • Competing interests None.

  • Patient consent Obtained from the parents.

  • Ethics approval Ethics approval was provided by the institutional review board of Far Eastern Memorial Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.