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MUC1 biosynthesis in human corneal and conjunctival epithelia
  1. Flavio Mantelli1,
  2. Pablo Argüeso2
  1. 1Department of Ophthalmology, Campus Bio-Medico University of Rome, Rome, Italy
  2. 2Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
  1. Correspondence to Dr Flavio Mantelli, Department Ophthalmology, Campus Bio-Medico University of Rome, Via Alvaro del Portillo, 21.00128 Rome, Italy; f.mantelli{at}

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We read with great interest the article by Barbaro et al (see page 926) who report that keratin 12 and the membrane-associated mucin MUC1 can be used as individual markers of corneal and conjunctival epithelia, respectively.1 The search for specific epithelial markers is of paramount importance for the diagnosis of ocular surface diseases (eg, limbal stem cell deficiency) because of limitations in current cytological methods.2 We believe, however, that the data presented in this manuscript do not justify the conclusion that MUC1 is restricted to conjunctival, …

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