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Functional and morphological macular abnormalities in membranoproliferative glomerulonephritis type II
  1. M Ritter1,
  2. M Bolz1,
  3. M Haidinger2,
  4. G Deák1,
  5. S Sacu1,
  6. M Säemann2,
  7. Ursula Schmidt-Erfurth1
  1. 1Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  2. 2Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
  1. Correspondence to Ursula Schmidt-Erfurth, Department of Ophthalmology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria;{at}

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Membranoproliferative glomerulonephritis type II (MPGN II) is a rare disease, characterised by the deposition of abnormal electron-dense material within the glomerular basement membrane of the kidney and within Bruch's membrane and the choriocapillaris in the eye.1 2 The long-term risk for visual problems is approximately 10%.

To our knowledge, there was no attempt to assess the high-definition morphological changes and the corresponding retinal function in different stages of this disease. Herein, we evaluate three cases of advanced, intermediate and early MPGN II by means of spectral domain optical coherence tomography (SD-OCT; Cirrus; Carl-Zeiss-Meditec, Dublin, California, USA) and report on the corresponding retinal function using microperimetry (MP1; Nidek, Gamagori, Japan).


Patient 1 (male, 50 years old, 28 years' disease duration)

The best-corrected visual acuity (BCVA) was 20/25 OD and 20/32 OS. Fundus examination revealed whitish drusen-like elevations scattered throughout the retina in both eyes. The OCT-A scans were characterised by retinal pigment epithelium (RPE) excrescences overlying an optically clear material, consistent with circumscribed serous RPE elevations. Overlying the excrescences, areas with compression of the photoreceptor layer including the inner/outer-segment junction …

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  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the Medical University of Vienna.

  • Provenance and peer review Not commissioned; externally peer reviewed.