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Correlation between fluorescein angiography and spectral-domain optical coherence tomography in the diagnosis of cystoid macular edema
  1. T Jittpoonkuson1,
  2. P M T Garcia2,3,
  3. R B Rosen2,3
  1. 1Retina Service, Department of Ophthalmology, the Bangkok Metropolitan Administration General Hospital (Central Hospital), Bangkok, Thailand
  2. 2Retina Center, Department of Ophthalmology, the New York Eye and Ear Infirmary (NYEEI), New York, New York, USA
  3. 3Department of Ophthalmology, New York Medical College (NYMC), Valhalla, New York, New York, USA
  1. Correspondence to Teerapat Jittpoonkuson, Retina Service, Department of Ophthalmology, The Bangkok Metropolitan Administration General Hospital, 514 Luang Rd, Pomprab District, Bangkok 10100, Thailand; dr.teerapat{at}


Aims To compare the ability to detect cystoid macular edema (CME) and its late complications between spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA).

Methods Retrospective, observational, case series. 85 Eyes who had FA and SD-OCT performed on the same day at first visit and/or at follow-up visits were included. FA and SD-OCT images were evaluated for the evidences associated with CME and other structural changes of macula. FA and SD-OCT images were then superimposed to determine the relationships of diagnostic features between the two images. Main outcome measure was the correlation between FA and SD-OCT findings of macula in patients with CME.

Results The common causes of CME in our study were retinal vein occlusion (RVO, 63%), diabetic retinopathy (DR, 21.18%) and posterior uveitis (3.53%). CME associated with RVO, age-related macular degeneration and DR were missed by FA in 18.52%, 33.33% and 33.33% of cases, respectively. Subretinal fluid was undetectable by FA in 54.55%, which mainly were in the RVO group. SD-OCT gave earlier CME diagnosis than FA in three (3.53%) eyes. Residual CME at follow-up visits were missed by FA in one (1.18%) eye. Late complications of long-standing CME (secondary macular hole (two eyes), secondary subretinal fluid (five eyes), retinal pigment epithelium detachment (one eye) and photoreceptor atrophy (one eye)) were detectable only by SD-OCT.

Conclusions SD-OCT demonstrated greater sensitivity than FA in detecting CME, particularly those associated with RVO, DR and age-related macular degeneration. SD-OCT was also more sensitive than FA for detecting subretinal fluid and late complications of long-standing CME.

  • Cystoid macular edema
  • fluorescein angiography
  • optical coherence tomography
  • diabetic retinopathy
  • retinal vein occlusion

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  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by the Ethics Committee of the New York Eye and Ear Infirmary, New York, USA.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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