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Lattice corneal dystrophy (LCD) type I is one of the five dominant TGFBI (transformimg growth factor β induced; formerly designated as bigh3 or keratoepithelin)-related corneal dystrophies with characteristic lattice-like refractile lines in the corneal stroma.1 Other than this common-type LCD, there have also been reported several minor-type LCDs caused by different mutations of the TGFBI gene.2
An 85-year-old man presented with complaints of bilateral blurred vision. His best-corrected visual acuity was 0.1 in OD and HM/30 cm in OS. He had bilateral corneal haze and cataract. The corneal haze contained many isolated or fused refractile opacities, most of them being dot-like, and some being lattice-like (figure 1A). The opacities were found at all depths of the corneal stroma, but mainly involved the deep stromal layer. The degree of corneal haze was severe in his left eye, but relatively mild in his right eye. His wife and two sons did not show any corneal opacity in their eyes. Cataract surgery was performed on his left eye, but his best-corrected visual acuity in that eye was improved …
Funding This work was supported by grants-in-aid (no 21592238) from the Japanese Ministry of Education, Science, Culture and Sports. This work was also supported by a research fund from the Kyoto Foundation for the Promotion of Medical Science.
Competing interests None.
Patient consent Obtained.
Ethics approval Ethics approval was provided by the Institutional Committee for Ethical Issues at Kyoto Prefectural University of Medicine.
Provenance and peer review Not commissioned; not externally peer reviewed.