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Funding This work was supported by grants-in-aid (no 21592238) from the Japanese Ministry of Education, Science, Culture and Sports. This work was also supported by a research fund from the Kyoto Foundation for the Promotion of Medical Science.
Competing interests None.
Patient consent Obtained.
Ethics approval Ethics approval was provided by the Institutional Committee for Ethical Issues at Kyoto Prefectural University of Medicine.
Provenance and peer review Not commissioned; not externally peer reviewed.