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  1. Christine M Clemson1,
  2. Radouil Tzekov1,
  3. Jenna M Checchi1,
  4. Mark Krebs2,
  5. Shalesh Kaushal1
  1. 1Department of Ophthalmology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
  2. 2University of Florida, Gainesville, Florida, USA
  1. Correspondence to Dr Shalesh Kaushal, Department of Ophthalmology, Eye Center, University of Massachusetts Medical School, 281 Lincoln Street, Worcester, MA 01605, USA; shalesh.kaushal{at}

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We appreciate the interest of van Schooneveld et al1 in our recent BJO article.2 Our small, retrospective chart review of retinitis pigmentosa (RP) patients treated off-label with valproic acid is only the first step in the process of understanding the potential utility of the drug for patients with this sight-threatening condition, for which there are no current therapeutic options.

The size and the scope of our article were limited by the nature of a retrospective chart review, which only allows analysis of follow-up that occurred within the defined time frame. Additional factors limiting the scope and length of the study included (1) the logistical and financial complexity …

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  • Linked articles 175356, 194373.

  • Competing interests None.

  • Ethics approval Ethics approval was provided by the University of Massachusetts Medical School IRB.

  • Provenance and peer review Not commissioned; not externally peer reviewed.

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