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In studying treatments for age-related macular degeneration (AMD), randomised controlled trials have typically used placebo or verteporfin in the control group.1 2 Hence, information on direct head-to-head comparisons between the newest agents is still needed.
Network meta-analysis (NMA) is a tool that summarises the information on comparative effectiveness when three or more treatments are proposed for the same clinical indication.3 4 NMA includes both direct comparisons (based on real trials) and indirect comparisons (based on statistical testing in the absence of a real head-to-head trial). The main advantage of NMA lies in its communicative value5; another advantage is that it overcomes one …
Competing interests None.